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|WASHINGTON Adidas Superstar Slip On Trainer Wit Goedkoop , Nov. 29 (Xinhua) -- U.S. researchers said Tuesday they have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, can block this infection, at least in brain cells grown in lab dishes.
Researchers at the University of California San Francisco (UCSF) reported that the Zika virus preferentially infects brain cells with an abundance of a protein called AXL, which spans the outer cell membrane of several cell types and serves as a gateway for the invading virus.
The fetal brain cells that incorporate this protein included neural stem cells and progenitor cells that eventually form other types of brain cells and that play an especially crucial role in early brain growth and development.
Other cells with AXL included microglia Adidas Superstar Foundation Zwart Wit B23642 Goedkoop , which are the brain's immune cells, and astrocytes, a fully developed and specialized type of brain cell that serves to support the signal-conducting neurons.
Neurons, which lack AXL, were not easily infected Heren Adidas Superstar 80s Pioneers Pharrel Zwart Wit Goedkoop , in contrast to what had been observed in mice previously used to study Zika infection.
The researchers then screened 2,177 U.S. Food and Drug Administration-approved drugs for their ability to block Zika infection of brain cells cultured in the lab, and identified several that did, including azithromycin, a widely used antibiotic.
The findings Adidas Dames Superstar 80S Metal Toe Core Goedkoop , published online in the U.S. journal Proceedings of the National Academy of Sciences, were led by Joseph DeRisi, chair of the UCSF Department of Biochemistry and Biophysics, and Arnold Kriegstein, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF.
"Our characterization of infection in the developing human brain clarifies the pathogenesis of congenital ZIKV (Zika virus) infection and provides the basis for investigating possible therapeutic strategies to safely alleviate or prevent the most severe consequences of the epidemic Adidas Superstar 2 Print Zwart Wit D65474 Goedkoop ," they concluded in their paper.
Zika is transmitted primarily by the tropical mosquito Aedes aegypti. It's estimated that between one percent and 13 percent of women infected during early pregnancy by the virus are giving birth to infants with microcephaly, a condition that is characterized by an undersized head and brain damage.
Currently, there is no treatment to prevent the Zika virus from harming the fetus, and the biological mechanism through which microcephaly arises as a result of infection remains unclear.
SANTIAGO, June 7 (Xinhua) -- Previously known as the worst team in the Copa America Adidas Superstar 2 Marine Goud D66092 Goedkoop , Venezuela has shown a significant improvement in recent years which may lead them to glory in this year's tournament.
In South American football, Venezuela have earned the nickname 'Cinderella', according to Copa America's official website, due to their low level of football and for being the only country within the South American Football Confederation (CONMEBOL) never to qualify for a World Cup, is this about to change?
Venezuela Adidas Superstar 2 Bling Zwart Goud G62844 Goedkoop , nicknamed 'The Burgundy', have had very few moments of glory throughout their history in the game and the majority of these moments have been in the XXI century.
Traditionally more of a baseball country, Venezuela's transformation began with their four consecutive victories during the final qualifying matches for the FIFA World Cup in Japan and South Korea putting the team ahead of Uruguay, Chile, Peru and Paraguay according to sports writer Jhonkarlos Guinan.
For any other country with a long-standing tradition of football this winning streak would not be anything out of the ordinary but for Venezuela Dames Adidas Superstar 2 Grijs Rood G17252 Goedkoop , it put an end to their chronic losing streak.
'The Burgundy' continued to improve on the road to Germany 2006, wrote Guinan in Copa America's official website. After suffering defeats against Ecuador and Argentina, Venezuela went on to win against Colombia, Bolivia and Uruguay however it wasn't enough to qualify for the World Cup 2006.
Off the back of their surprising results in the World Cup qualifier, Venezuela hosted the Copa America in 2007. The team topped their group which included Peru Dames Adidas Superstar Blauw Wit 909244 Goedkoop , Bolivia and Uruguay and went as far as the quarter finals in the tournament for the first time in history.
Venezuela's 2-0 win over Peru in that tournament marked their first win in the contest since 1967.
After this result 'The Burgundy' became more hungry than ever for victory and especially focused on qualifying for a World Cup.
With a change of manager from Richard Paez to Cesar Farias the team went from strength to strength qualifying for the Under 20s World Cup and they were only two points away from reaching the World Cup South Africa 2010. That were the closest they had ever been.
While the world was watching South Africa, Farias began a renovation process within the squad which involved playing 20 friendlies, trying over 60 footballers in any set up and formation.
Continuing with the regeneration of the team, before the Copa America 2011, Venezuela went to Dallas Dames Adidas Superstar 2 Wit Rood 919618 Goedkoop , United States to play a pre-season to get them ready for the tournament.
The Copa America 2011 was very important for the South American side as it marked the start of the path to the World Cup 2014 in Brazil.
After more than a year of intensive training, 'The Burgundy' surprised everyone by playing with a high level to draw with Brazil in their first match of the tournament.
From that day, many people forgot about the team's past humiliations said Guinan. Venezuela went on to win the fourth place in the contest after losing in penalties to Paraguay in the semi-final.
The Copa America 2011 confirmed Venezuela's progress in recent years. To finish in the top four of the oldest football tournament in the world is obviously an important highlight in 'The Burgundy's' short history.
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